Apigenin
Flavonoid from chamomile; gentle sleep and relaxation support.
By Suplagen Team · Updated
What it is
Apigenin is a flavonoid abundant in chamomile. It binds to benzodiazepine receptors at sub-sedative levels, promoting calm without heavy drowsiness.
How it works
Binds to GABA-A benzodiazepine site as a weak partial agonist; provides anxiolytic effects without full sedation.
What the evidence says
Emerging evidence; mostly extrapolated from chamomile research. Mechanistically promising but human trials are limited.
How much to take
The catalog range is 50 to 100 mg, and 100 mg is the ceiling. It's the chamomile compound concentrated, and the evidence is emerging, mostly extrapolated from chamomile research rather than trials of apigenin itself.
Start at 50 mg. It's gentle enough for nightly use, and there's no evidence that more helps.
When and how to take it
30 to 60 minutes before bed. It's often stacked with magnesium and L-theanine, and it fits our sleep guide as a supporting act rather than a lead.
With or without food; it has no absorption rules.
Who should skip it
Pregnancy and breastfeeding are cautions. One mild interaction: sedatives and benzodiazepines, since apigenin acts weakly on the same GABA-A site and can add to their effect. Otherwise well tolerated.
Safety Notes
- Gentle enough for nightly use. Often stacked with magnesium and L-theanine for sleep.
- Use caution with: pregnancy/breastfeeding (caution).
- sedatives / benzodiazepines: Additive effects at benzodiazepine receptor; use caution.
Common questions
How much apigenin should I take for sleep?
50 to 100 mg, 30 to 60 minutes before bed. 100 mg is the ceiling; start at 50.
Is apigenin the same as chamomile?
It's the main active compound in chamomile, concentrated. Most of its evidence comes from chamomile research, which is why the grade is emerging rather than moderate.
Can I take apigenin every night?
Yes. The catalog notes it's gentle enough for nightly use, unlike melatonin, which favors intermittent dosing.