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ALA
Antioxidants
Alpha-Lipoic Acid (ALA)
Studied for diabetic neuropathy symptoms; 600 mg/day is common.
What it is
ALA has moderate evidence for symptom improvement in diabetic peripheral neuropathy; glucose-lowering interactions are relevant.
How it works
Redox-active antioxidant; may reduce oxidative stress involved in neuropathic symptoms.
What the evidence says
Moderate evidence for diabetic neuropathy symptom relief; monitor glucose and medication interactions.
Safety Notes
- Many reviews highlight ~600 mg/day as a common oral dosing in trials, with higher doses used in some studies.
- Not recommended during pregnancy or while breastfeeding.
- Use caution with: hypoglycemia-prone states (caution).
- antidiabetes medications: Potential additive glucose lowering; monitor for hypoglycemia.