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O3
Fatty Acids
Omega-3 Fish Oil (EPA+DHA)
Most consistent supplement effect is triglyceride lowering at higher doses.
What it is
Fish oil provides EPA and DHA. High-dose use for triglycerides is typically clinician-directed; lower doses are used for general nutrition with mixed outcome evidence.
How it works
Modulates lipid metabolism and inflammatory signaling; higher doses lower triglycerides.
What the evidence says
Strongest for triglyceride lowering; cardioprotection evidence depends on dose/formulation and population.
Safety Notes
- FDA-linked guidance commonly references a 3 g/day EPA+DHA ceiling (including ≤2 g/day from supplements) without supervision.
- Use caution with: bleeding disorders (caution), fish allergy (caution).
- warfarin and other anticoagulants/antiplatelets: High doses may increase bleeding risk; monitor clinically.