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B9
Vitamins

Folate (Folic Acid / Methylfolate Products)

Critical for DNA synthesis; high folic acid can mask B12 deficiency.

What it is

Folate supports cell division and is essential in pregnancy; excessive folic acid can mask B12 deficiency.

How it works

One‑carbon metabolism and nucleotide synthesis; high folic acid may conceal hematologic signs of B12 deficiency.

What the evidence says

Strong evidence for appropriate periconceptional folate; key safety issue is masking B12 deficiency at high doses.

Safety Notes

  • UL (1,000 mcg/day) applies to folic acid (synthetic), not naturally occurring food folate.
  • Use caution with: untreated vitamin B12 deficiency.

Timing With Other Supplements

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