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PS
Nootropics
Phosphatidylserine (PS)
Phospholipid supporting cell membrane integrity and cortisol modulation.
What it is
Phosphatidylserine is a phospholipid critical for cell membrane structure, especially in neurons. It may blunt exercise-induced cortisol.
How it works
Integral membrane phospholipid; supports neuronal signal transduction, neurotransmitter release, and cortisol regulation.
What the evidence says
Moderate evidence for cognitive support in older adults; emerging evidence for cortisol blunting during exercise.
Safety Notes
- Modern supplements use soy or sunflower-derived PS (not bovine brain-derived).
- anticoagulants: Theoretical interaction; monitor if on blood thinners.
- anticholinergic drugs: May counteract anticholinergic effects.